Immunotherapy & Tumor Biology
By dissecting tumor microenvironments and immune‑cancer cell interactions, this group identifies checkpoints and antigens critical for anti‑tumor immunity. They develop and test novel payloads—such as engineered T cells, bispecific antibodies, and oncolytic viruses—to boost selective cancer cell killing.
Their translational pipeline moves promising candidates from bench to early‑phase trials, with the goal of improving efficacy and reducing off‑target effects in solid and hematologic malignancies.
Francesca Neville
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Frank Denver
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Ingrid Larsson
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The labs of Professors Francis Impens and Lennart Martens at the VIB-UGent VIB-UGent Center for Medical Biotechnology have joined a new EU project, COMBINE, researching the Marburg virus (MARV). The project sets out to advance our understanding of how viruses enter cells, using MARV as a model, and to ...
De Schepper Lab
Bridging bench discoveries to therapies for nervous system repair.
- 04-03-2025
Nanobodies Targeting the Tumor Microenvironment and Their Formulation as Nanomedicines.
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- 18-11-2015
Membrane Protein Expression and Analysis in Yeast
This protocol describes the expression and analysis of membrane proteins produced in yeast, as illustrated with Yarrowia lipolytica and Pichia pastoris. Step by step, we explain how to generate a yeast strain expressing the membrane protein of interest, how to prepare a membrane protein sample from yeast, and how (...)
Erc-funded Postdoctoral Position Focusing on Nanobody Development for Therapeutic Brain Delivery
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TCP domains: {acf_job_domain}Experienced Light Microscopist
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TCP domains: {acf_job_domain}Flow Cytometry Data Analysis Expert
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Enzyme‑driven Plastic Waste Bioremediation
Engineering robust enzymes to degrade persistent polymers.
Combining directed evolution and computational modeling, we develop enzymes capable of rapidly breaking down PET and related plastics. Studies will assess catalytic efficiency, thermal stability, and integration into safe microbial chassis. Pilot‑scale demonstrations aim to validate environmental impact and biorecycling potential.
Patient‑derived Organoid Platforms for Personalized Medicine
Using organoid cultures to predict individualized drug responses.
By growing mini‑organs from patient biopsy samples, we create high‑throughput drug screens tailored to each individual’s tumor or genetic disease. Integrated genomic and pharmacodynamic analyses will pinpoint optimal therapies. This approach seeks to streamline personalized treatment decisions in clinical settings.
Smart Nanocarrier Platforms for Targeted Drug Delivery
Designing responsive nanoparticles to deliver therapeutics with pinpoint accuracy.
This project engineers stimuli‑responsive nanocarriers that only release their payload at disease sites, leveraging pH‑ and enzyme‑sensitive polymers. In vitro assays and animal models will evaluate biodistribution, controlled release kinetics, and therapeutic efficacy. The ultimate goal is a safe, scalable platform for precision medicine applications.
