Cellular Signal Transduction
This group investigates the molecular pathways by which cells perceive and respond to external and internal cues. By mapping key receptors, kinases, and second messengers, they aim to reveal how normal signaling maintains homeostasis and how its dysregulation leads to disease.
Their work lays the groundwork for novel diagnostics and targeted therapies in areas such as neurodegeneration, metabolic disorders, and inflammatory conditions.
Nico Callewaert
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Boris Benno
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Cristina Lavazza
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Frank Denver
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- 03-03-2025
Dual and Spatially Resolved Drought Responses in the Arabidopsis Leaf Mesophyll Revealed by Single-cell Transcriptomics.
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- 25-06-2010
Isolation of Antigen-binding Camelid Heavy Chain Antibody Fragments (nanobodies) From an Immune Library Displayed on the Surface of Pichia Pastoris
Yeast surface display is an efficient tool for isolating and engineering antibody fragments, both scFv and Fab. We describe the use of protein display on Pichia pastoris for the rapid selection of camelid antibodies composed only of heavy chains (nanobodies) from a library derived from a llama immunized with Green (...)
Bioinformatician Postdoctoral Level
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TCP domains: {acf_job_domain}Data Science and AI Trainer
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TCP domains: {acf_job_domain}10% Associate Professor Ugent
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Crispr‑enhanced T Cell Therapies
Reprogramming patient immune cells for precision cancer immunotherapy.
Utilizing CRISPR/Cas9, we edit T cells to boost tumor‑homing receptors and resist inhibitory signals within the tumor microenvironment. Preclinical safety and persistence studies will inform protocol optimization. This translational pipeline aims to advance lead candidates into first‑in‑human trials.
