Vib-uantwerp Center for Molecular Neurology
- 04-03-2025
Nanobodies Targeting the Tumor Microenvironment and Their Formulation as Nanomedicines.
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- 03-03-2025
Replication Stress, Microcephalic Primordial Dwarfism, and Compromised Immunity in Atrip Deficient Patients.
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- 18-11-2015
Membrane Protein Expression and Analysis in Yeast
This protocol describes the expression and analysis of membrane proteins produced in yeast, as illustrated with Yarrowia lipolytica and Pichia pastoris. Step by step, we explain how to generate a yeast strain expressing the membrane protein of interest, how to prepare a membrane protein sample from yeast, and how (...)
- 25-06-2010
Isolation of Antigen-binding Camelid Heavy Chain Antibody Fragments (nanobodies) From an Immune Library Displayed on the Surface of Pichia Pastoris
Yeast surface display is an efficient tool for isolating and engineering antibody fragments, both scFv and Fab. We describe the use of protein display on Pichia pastoris for the rapid selection of camelid antibodies composed only of heavy chains (nanobodies) from a library derived from a llama immunized with Green (...)
Enzyme‑driven Plastic Waste Bioremediation
Engineering robust enzymes to degrade persistent polymers.
Combining directed evolution and computational modeling, we develop enzymes capable of rapidly breaking down PET and related plastics. Studies will assess catalytic efficiency, thermal stability, and integration into safe microbial chassis. Pilot‑scale demonstrations aim to validate environmental impact and biorecycling potential.
Crispr‑enhanced T Cell Therapies
Reprogramming patient immune cells for precision cancer immunotherapy.
Utilizing CRISPR/Cas9, we edit T cells to boost tumor‑homing receptors and resist inhibitory signals within the tumor microenvironment. Preclinical safety and persistence studies will inform protocol optimization. This translational pipeline aims to advance lead candidates into first‑in‑human trials.
Smart Nanocarrier Platforms for Targeted Drug Delivery
Designing responsive nanoparticles to deliver therapeutics with pinpoint accuracy.
This project engineers stimuli‑responsive nanocarriers that only release their payload at disease sites, leveraging pH‑ and enzyme‑sensitive polymers. In vitro assays and animal models will evaluate biodistribution, controlled release kinetics, and therapeutic efficacy. The ultimate goal is a safe, scalable platform for precision medicine applications.
